2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Hippo (MST)
  5. Hippo (MST) Inhibitor

Hippo (MST) Inhibitor

Hippo (MST) Isoform Comparison

Hippo (MST) Inhibitors (13):

Cat. No. Product Name Effect Purity
  • HY-100526
    XMU-MP-1
    		Inhibitor 99.93%
    XMU-MP-1 is a reversible and selective MST1/2 inhibitor with IC50s of 71.1 and 38.1 nM, respectively.
  • HY-101275
    EMT inhibitor-1
    		Inhibitor 99.82%
    EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.
  • HY-128206
    I3MT-3
    		Inhibitor 99.76%
    I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM). I3MT-3 is inactive for other H2S/sulfane sulfur-producing enzymes.?I3MT-3 targets a persulfurated cysteine residue located in the active site of 3MST.
  • HY-151257
    IHMT-MST1-58
    		Inhibitor 99.05%
    IHMT-MST1-58 is a potent, selective mammalian and orally active STE20-like protein 1 kinase (MST1) inhibitor with IC50 value of 23 nM. IHMT-MST1-58 can be used for the research of Type 1/2 diabetes.
  • HY-175208A
    MST3-IN-1 TFA
    		Inhibitor 99.38%
    MST3-IN-1 TFA (Compound LD-1) is a selective and orally active MST3 inhibitor, with an IC50 of 122.4 nM. MST3-IN-1 TFA shows antiproliferative activity against HepG2 cell. MST3-IN-1 TFA effectively induces Apoptosis in HepG2 cells, and halts the cell cycle at the G2/M transition. MST3-IN-1 TFA significantly suppressed tumor growth in HepG2 xenograft mice. MST3-IN-1 TFA can be used for the study of liver cancer.
  • HY-114804
    BRD2577
    		Inhibitor
    BRD2577 is a selective mercaptopyruvate sulfurtransferase (3-MST) inhibitor with an IC50 of 9.9 μM. BRD2577 inhibits H2S production in colon carcinoma cells. BRD2577 exhibits weak to no significant inhibitory effect on colon cancer cell proliferation and mitochondrial activity. BRD2577 can be used for the research of colon cancer.
  • HY-160211
    JA310
    		Inhibitor 99.83%
    JA310, a chemical probe, is a highly selective MST3 kinase inhibitor. JA310 has high cellular potency against MST3 with an EC50 value of 106 nM.
  • HY-164595
    IHMT-MST1-39
    		Inhibitor 99.68%
    IHMT-MST1-39 is an orally active inhibitor for MST kinase, with IC50 of 42, 109, 286, 159 nM for MST1, MST2, MST3, MST4. IHMT-MST1-39 activates the AMPK signaling pathway in liver cells, reduces apoptosis of pancreatic β-cells. IHMT-MST1-39 can be used for the studies of type 1 diabetes (T1D) and type 2 diabetes (T2D).
  • HY-157932A
    MR24 TFA
    		Inhibitor 99.13%
    MR24 TFA, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 TFA shows selectively to MST3/4 over MST1/2, with EC50 values of 57 and 583 nM, respectively. MR24 TFA induces G1 phase cell cycle arrest. MR24 TFA can be used for cancer research, such as breast, liver and lung cancers.
  • HY-175208
    MST3-IN-1
    		Inhibitor
    MST3-IN-1 is a selective and orally active MST3 inhibitor, with an IC50 of 122.4 nM. MST3-IN-1 shows antiproliferative activity against HepG2 cell. MST3-IN-1 effectively induces apoptosis in HepG2 cells, and halts the cell cycle at the G2/M transition. MST3-IN-1 significantly suppressed tumor growth in HepG2 xenograft mice. MST3-IN-1 can be used for the study of liver cancer.
  • HY-100526R
    XMU-MP-1 (Standard)
    		Inhibitor
    XMU-MP-1 (Standard) is the analytical standard of XMU-MP-1 (HY-100526). This product is intended for research and analytical applications. XMU-MP-1 is a reversible and selective MST1/2 inhibitor with IC50s of 71.1 and 38.1 nM, respectively.
  • HY-157932
    MR24
    		Inhibitor
    MR24, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 shows selectively to MST3/4 over MST1/2, with EC50 values of 57 and 583 nM, respectively. MR24 induces G1 phase cell cycle arrest. MR24 can be used for cancer research, such as breast, liver and lung cancers.
  • HY-101275R
    EMT inhibitor-1 (Standard)
    		Inhibitor
    EMT inhibitor-1 (Standard) is the analytical standard of EMT inhibitor-1 (HY-101275). This product is intended for research and analytical applications. EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.